EndoTrap® family: Endotoxin removal products

Notification: The complete EndoTrap product range has been discontinued by Hyglos as of 31 December 2017, instead LIONEX GmbH, Braunschweig, Germany, is now the supplier and exclusive supplier of these products.

Please contact LIONEX at:

Salzdahlumer Strasse 196, Geb. 1A
38126  Braunschweig, Germany


EndoTrap® removes endotoxins (lipopolysaccharides/LPS) from aqueous solutions of a wide range of samples such as proteins, antibodies, vaccines, nucleic acids, buffers and cell extracts with excellent sample recovery rate.
EndoTrap® has been used for the elimination of endotoxin in more than 200 publications.

New Performance Data for EndoTrap®

A new study describes the efficiency of four endotoxin removal resins from different suppliers including EndoTrap®. EndoTrap® HD supplied by Hyglos was shown to be the most effective resin for removing endotoxins and recovering protein in comparison to the other resins tested.

EndoTrap Endotoxin Removal Kits for non-toxic & highly specific LPS removal


  • Best-in-class endotoxin binding capacity of > 5,000,000 EU/ml
  • Removes more than 99.99%* of LPS
  • Excellent sample recovery rate >95%*
  • Non-toxic bacteriophage-derived ligand, no cytotoxic effects
  • Re-use more than 10 times
  • Quick and easy to use in column (gravity flow) or batch mode
  • Up-scaling on fully automated liquid-chromatographic systems possible

Products & Applications:

EndoTrap® redEndoTrap® HD
LPS binding capacity:> 2,000,000 EU/ml resin> 5,000,000 EU/ml resin
Reusability:3 timesMore than 10 times
pH sample buffer:6-94-10
Suitable Buffers:Calcium chelatorsSuitable for high salt conditions
(> 150 mM NaCl)
Sample Applications:Proteins,
Plant extracts,
Automated systems,
Biomanufacturing processes
*Measured values for BSA, MAK (monoclonal antibody) and POD (peroxidase) with EndoTrap HD®.

For further characteristics (sample concentration, detergents, bacterial strains) see "Short introduction into the EndoTrap® family" (page 2).

For a list of purified samples and recommended EndoTrap® resins see the Costumer Application List.

For further information please see the Frequently Asked Questions (FAQ) about EndoTrap® or contact Hyglos' technical support team.

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1. Lorenz, Natalie et. al. (2013) in: Immunology and Cell Biology
2. Schlapschy, Martin et. al. (2013) in: Protein Engineering Design and Selection
3. Katakura, Fumihiko et. al. (2013) in: Developmental & Comparative Immunology
4. Stano, Armando et. al. (2013) in: Biomaterials
5. Akiyama, Hironori et. al. (2013) in: Molecular and Cellular Endocrinology
6. Banik, Stefanie et. al. (2013) in: Infection and Immunity
7. Triantafilou, Martha et. al. (2013) in: PLoS ONE
8. Lee, Haeyong et. al. (2013) in: Biochimica et Biophysica Acta

Here you can find more publications and reference costumers.