Innovation in Endotoxin Testing ensuring patient safety and scientific soundness - without using Horseshoe Crabs!

Hyglos GmbH - a bioMérieux company - is the endotoxin unit of bioMérieux, located in Biotechnology Center Bernried, Munich area, Germany. We have a strong focus on innovation in the field of Endotoxin Detection and our sustainable assays are based on Phage Recombinant Proteins and Recombinant Horseshoe Crab Factor C (rFC), produced completely without using the blood from horseshoe crabs.

NEW in 2018: ENDOZYME® II GO - faster, easier and more consistent endotoxin testing featuring GOPLATETM. Read more about our products and services on:

Since 1 July 2016, our endotoxin test methods are included in Chapter 5.1.10 of the European Pharmacopoeia as approved alternative methods. Our endotoxin tests bring important advantages to users in biopharmaceutical research and industry, overcoming limitations of the LAL test (Limulus amebocyte lysate) which still relies on lysate from the blood of the horseshoe (Limulus) crab. Hyglos has also developed a world-first sample preparation method for full recovery of endotoxin in samples affected by Low Endotoxin Recovery (LER). Hyglos offers a comprehensive services for LER, including hold-time studies according to the FDA requirements as well as full demasking protocol development.

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