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ENDONEXT™

BETTER FOR YOUR LAB. BETTER FOR THE PLANET.

ENDONEXT™ endotoxin detection assays are ushering in a new era of smarter, more sustainable pharmaceutical quality control.

Product Details

Based on recombinant Factor C (rFC), ENDONEXT™ technology not only eliminates the need to harvest horseshoe crab blood, but also makes your laboratory more efficient. With 100% endotoxin specificity, lot-to-lot consistency, and more streamlined workflows, ENDONEXT™ provides reliable results everywhere from in-process controls to final product testing on the most complex matrices.

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Features

  • Easy automation with robotic liquid-handling systems
  • Fluorescence end-point assays in a 96-well microplate format

Main Benefits

  • 100% endotoxin specificity

  • High lot-to-lot consistency

  • Ecologically sustainable

  • Validated according to standard pharmacopoeia Bacteria Endotoxin Testing criteria

WHITE PAPER

Waste reduction in endotoxin testing

From traditional to alternate endotoxin testing methods used for product release testing, there is an opportunity to waste less reagent and generate cost savings.

WHITE PAPER

ENDOZYME® II GO automation solution for endotoxin testing

The Tecan Fluent® workstation has been paired with the bioMérieux ENDOZYME® II GO pre-coated plates to create a seamless automation solution for endotoxin testing.

Innovative Endotoxin Testing

Recombinant Factor C: Advanced Endotoxin Testing

Our endotoxin detection solutions are specifically designed to meet the need for quick, smart, and agile laboratory tools

WHITE PAPER

Bacterial Endotoxin Testing

Recombinant horseshoe crab Factor C (rFC) methods are the latest state-of-the-art solution for effective bacterial endotoxin testing (BET). This whitepaper reviews the advantages of Recombinant horseshoe crab Factor C (rFC) over the BET methods currently in widespread use. We compare the performance of LAL reagents with rFC, and summarize the evidence supporting our 10 reasons to choose rFC.

WHITE PAPER

What is driving the adoption of rFC for bacterial endotoxin testing?

As industry leaders seek strategies to build supply chain resilience, multi-sourcing is driving the adoption of alternative solutions like rFC.

WHITE PAPER

The Hunt for the Missing Endotoxin

This white paper reviews the causes contributing to low endotoxin recovery (LER), the impact it creates, as well as solutions which can rectify the issues it results in. We also discuss the advantages and disadvantages of developing your de-masking protocols in-house, and how you can use the ENDO-RS® de-masking tool kit to make the process easier from beginning to end. Following this, we outline the pros and cons of outsourcing your de-masking project, what you should look for in a third-party company, and why you can and should trust bioMérieux with your de-masking protocol development.

Tests

We make endotoxin testing FASTER, EASIER, and ENVIRONMENTALLY FRIENDLY, plus lot-to-lot consistency gives you confidence in your in-process control and product release decisions. Explore the ENDONEXT™ range of products.

ENDOZYME® II

The enhanced second generation of ENDOZYME® is a flexible and easy-to-use endotoxin detection assay.

  • State-of-the-art sensitivity down to 0.001 EU/mL
  • Flexible assay time depending on required sensitivity
  • Particularly suited for final product testing, formulation and research

ENDOZYME® II GO

The rapid GO version of ENDOZYME®II featuring GOPLATE™ - a microplate pre-filled with required standard curve and positive product control concentrations (PPC).

  • Eliminates manual preparation of standard dilutions and PPCs
  • Over 50% reduction in handling time compared to conventional microplate assays
  • Significantly reduces risk of error
  • Ideal for in-process control of water and raw materials as well as product release testing
  •  Easy automation

ENDOZYME® II GO STRIPS

ENDOZYME® II GO STRIPS contain all of the benefits of ENDOZYME® II GO with simple and consistent use due to the CSE pre-coated wells, with the flexibility to test anywhere from 1 to 21 samples with minimal waste.

Laboratories do not always have 20 samples to fill a full plate; ENDOZYME® II GO STRIPS are designed with flexibility in mind— flexible number of samples and flexible testing timing.

 

ENDOLISA®

With its unique built-in sample preparation step, the ENDOLISA® assay revolutionizes endotoxin testing of complex samples.

  • ELISA-like format features 96-well plate pre-coated with a specific endotoxin-binding phage protein
  • Overcomes limits of traditional methods such as inhibition and enhancement
  • Unprecedented tolerance of organic solvents, detergents

Downloads

Brochure - ENDONEXT™ - The Evolution of Endotoxin Testing

Download

Filename
PHARMA_BROCHURE_ENDONEXT_A4_05_23_9324113_Pages.pdf
Size
488 KB
Format
application/pdf

Brochure - ENDONEXT™ Software -  Your new Lab Assistant Efficient and 21 CFR Part 11 compliant

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Filename
BROCHURE_ENDONEXT_SOFTWARE_A4_05_23_9324112.pdf
Size
277 KB
Format
application/pdf

Brochure - ENDOZYME® II - Recombinant Factor C (rFC) Endotoxin Detection Assay

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Filename
Flyer_ENDOZYME II.pdf
Size
867 KB
Format
application/pdf

Brochure - ENDOZYME® II GO - Endotoxin Testing Made Faster, Easier, and Sustainable. Ally Friendly.

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Filename
PHARMA_BROCHURE_EZIIGO_A4_05_23_9324100_Pages.pdf
Size
574 KB
Format
application/pdf

Brochure - ENDOZYME® II GO Strips - Do you need flexible Endoxotin testing?

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Filename
PHARMA_BROCHURE_EZIIGO_STRIPS_A4_05_23_9324100_Pages2.pdf
Size
483 KB
Format
application/pdf

Brochure - ENDOLISA® - Endotoxin Detection Assay Based on ELISA-Technology and Recombinant Factor C (rFC)

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Filename
Flyer_ENDOLISA.pdf
Size
920 KB
Format
application/pdf

Citation List - Recombinant Factor C (rFC) Assay

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Filename
BMX_rFC_Citation_List_2010_2022_Final.pdf
Size
74 KB
Format
application/pdf

ENDONEXT™ The Evolution Of Endotoxin Testing

Eliminates the need to harvest horseshoe crab blood and helps make quality control more precise and efficient.